[Guest Post] Griffs Cholesterol Primer

by Paleo Rob on 29/08/2010

Note from Paleo_Rob

This was a post from the Marks Daily Apply forum (Original found here) that Griff graciously let me re-post here. It is a great resource and taught me a lot. I hope everyone else enjoys it as much as I did.

I have not changed the content of the post but have edited it slightly to clean it up and make it more readable in the blog setting. Again for an unadulterated view, check the original post linked above.

For cholesterol numbers, the values given are in non-SI units mg/dL where as we Aussies use mmol/L. To convert these numbers we use these simple formulas.

Total Cholesterol/LDL/HDL = Number / 38.67
Triglycerides = Number /  88.57

DEFINITIONS OF TERMS


Total Cholesterol: This is the total of all three kinds of cholesterol: HDL + LDL + Triglycerides. Each of them has a different function inside the body.
The recommended level of total cholesterol these days is 200 or less.


Cholesterol: A waxy substance that is actually an alcohol (hence the -ol suffix). It’s carried by lipoproteins (fats and proteins) through the water-based environment of the bloodstream (remember that water and oil don’t mix). It’s necessary to sustain cell wall integrity and to repair damaged cell walls within (among other places) the arterial system of the body. Many things can damage the cell walls in the arteries and veins, including (but not limited to) stress, high blood sugar, high insulin levels, and lack of physical activity. When damage happens to these cell walls, the body has to do something about it. Normally, it will repair them with saturated fat and protein, which is what cell walls are made of, but if we’re not eating those things, the body can’t produce them out of thin air, so it sends cholesterol in as a stopgap measure. Your body uses cholesterol to make a "patch" over cell walls that need to be repaired, but if we don’t give it the proper amount of raw materials (saturated fat and protein) to repair them with, the patch will stay there, and like any old bandage, eventually start to peel off. In the absence of the proper raw materials, the body slaps another layer of cholesterol over them to make sure that the patch doesn’t break. This is where cholesterol buildup, or plaque, in the arteries comes from. The longer the body has to go without the right raw materials, the worse the problem gets, and these plaques can eventually break off, just like a scab on the outside of your body does, and block up the arteries, causing a heart attack or a stroke. The technical term used for "increases risk of heart disease" is "atherosclerotic," which, translated out of its non-English roots, means "athero" (artery) "sclerotic" (hardening).


One of the problems with the way that current medical science treats cholesterol is that it doesn’t recognize the function of cholesterol. It just sees higher cholesterol readings and naively assumes that since high cholesterol and heart disease "seem" to go together, that cholesterol must be the cause of heart disease. The real cause of heart disease is what causes both the damage to the cell walls and the (ideally) temporary patches of cholesterol: not enough of the right raw materials being given to the body, and too much of the stuff that damages the cell walls being given to the body – to wit, too many carbs and not enough saturated fat or protein. It’s like blaming firemen for a fire, or blaming a bandage for the wound, and saying "if we take away some firemen, the fire will die out," or "if we take the bandage off the wound, the wound will heal without help" (even though it’s usually a wound that needs stitches in order to close up and heal). It’s overly simplistic, it’s a junior-high-school-level mistake, and it makes no sense.


LDL (Low-Density Lipoprotein): This has been blamed as the "bad" cholesterol because its job is to go around inside your body, bringing cholesterol from the liver to spots that need repair, and placing cholesterol "patches" on them. There are two types: Pattern A and Pattern B. Sometimes you’ll have a mixed bag: Pattern A/B, some of each. When you have a VAP test, this is part of what gets reported. Pattern A is "large and fluffy" and non-atherosclerotic, like a cotton ball. Pattern B is "small and dense" and atherosclerotic, like a BB pellet. You want to have Pattern A. Pattern B is sometimes called "oxidized"cholesterol, and because it’s so small and dense, it can penetrate the endothelium (the thin layer of cells that line the inside of the blood vessels), just like a BB pellet penetrates skin. So Pattern B LDL is worrisome, because it can also cause damage to the cell walls inside the arteries. LDL becomes Pattern B due to a number of reasons, but one of the main ones is insulin resistance. If you lower your insulin resistance (which low-carbers almost always manage to do), then your LDL Pattern B goes down, which is good.The recommended level of LDL these days is no more than 150, and most doctors now want it below 100.


HDL (High-Density Lipoprotein): This is considered the "good" cholesterol because its job is to go around inside your body and clean up used cholesterol. HDL goes around after the patched area has been repaired, and cleans up the old cholesterol patches, taking them back to the liver for processing and breakdown. You can see why HDL is high-density: it carries old cholesterols with it to the liver, so it’s got lots of tightly-packed stuff on it, hence high-density. Low-density LDL is just the opposite – it’s dropping cholesterol here and there, so it’s no longer as dense.
The recommended level of HDL these days is at least 40 for women and 50 for men. Some recommendations are "get it above 60."

Triglycerides: The "cholesterols" made in the liver from the carbs you eat. They are technically not cholesterol at all, but fat. They’re used by cells for energy. A third kind ofcholesterol called VLDL (very low-density lipoprotein) carries triglycerides around in the body, delivering them to cells for energy. When VLDLs lose most of their triglycerides, they become smaller and denser, and now they’re LDLs instead of VLDLs. Triglycerides can shoot the level of VLDL way, way up – the more triglycerides you have, the more VLDL is needed to move it around the body. So if you’re eating lots of carbs, your triglycerides are going to be higher, and since VLDL becomes LDL when it deposits its triglycerides into the cells, your LDL will also be higher.
The recommended level of triglycerides these days is under 150.

EQUATIONS USED FOR CHOLESTEROL MEASUREMENT

Paleo_Rob Note: If you don’t want to do all the calculations yourself, use the tool on this website to calculate all your ratios and Iranian LDL. Find it here.

There are two equations used today for cholesterol measurement. The first one, and the one most commonly used, is called the Friedewald equation. It works fine as long as your triglycerides are at least 100 and below 400, but outside of that range things get wonky. And the main problem is, when your triglycerides are below 100, it overestimates LDL levels.

A quick rundown:
The Friedewald formula used to calculate total cholesterol is:
LDL + HDL + [Trigs/5] = total.
But because LDL are so small in comparison to the other particles, what they usually do is calculate your LDL. They measure your HDL, your Trigs and your Total – so the equation becomes:
Total – (HDL + [Trigs/5]) = LDL.
(I don’t know why the triglycerides are divided by 5. I haven’t yet found that out.)


Because this equation miscalculates LDL if you drop below 100 trigs, I’d recommend that you always, always demand a VAP test, which is a direct measurement of the LDL. People who restrict carbs usually have very low triglycerides, which means that we’re going to have problems if the lab uses the Friedewald equation to calculate our LDL levels. According to Dr. Mary Vernon, "These labs in which the LDL is calculated are not accurate if your triglycerides are below 100… The equation used to calculate these numbers makes assumptions which are not accurate when triglycerides are low." (from http://www.livinlavidalowcarb.blogsp…t-results.html).

To give an example of how it doesn’t calculate LDL correctly, let’s look at a hypothetical cholesterol result. Let’s say that Joe the Primal Dude goes in for a lipid profile after six months on the Primal diet. Here’s his results (before they do the LDL calculation):
Total: 250 (ideal <200)
HDL: 70 (ideal >60)
LDL: ? (must be calculated) (ideal <100)
Trig: 40 (ideal <150)
This is a common profile for someone who’s been low-carbing/eating Primally for a while. Now, when we put that into the Friedewald equation, here’s what we get:
250 – (70 + (40/5)) = LDL
250 – (70 + 8) = LDL
250 – 78 = LDL
250 – 78 = 172

This may give Joe’s doctor a heart attack if he doesn’t know what he’s looking at, as many doctors don’t. To him, Joe’s LDL and total cholesterol levels are way above the "ideal" numbers, and that must mean that Joe is headed for a heart attack or a stroke if he doesn’t take a statin drug immediately and get those numbers down.

For many doctors, this level of analysis is as far as they go. The nuanced information about the two types of LDL is something they either don’t have or aren’t aware of. And recognizing that if Joe’s HDL were lower, his total cholesterol would be lower too – they don’t often see that, either.
However, there is a newer equation, called the Iranian Equation, that does a better job of calculating LDL when trigs are below 100. That equation is:
(Total/1.19) + (Trig/1.9) – (HDL/1.1) -38 = LDL
Let’s plug Joe’s numbers into this equation and see what we get.
(250/1.19) + (40/1.9) – (70/1.1) – 38 = LDL
210 + 21 – 64 – 38 = LDL
231 – 102 = 129
Look at that. It’s a difference of almost 50 points in Joe’s favor. With the Iranian equation, his numbers come out to:
Total: 250
HDL: 70
LDL: 129
Trig: 40
Part of the reason the Friedewald equation doesn’t work so well is that Trig/5 issue. The Friedewald equation assumes that anything that isn’t HDL or triglycerides is LDL. LDL is the "leftover" number. Well, when your trigs are 200/5, the number it will subtract from the overall total is 40, but when your trigs are 40/5, the number it will subtract from the overall total is 8. That’s a big difference, because the smaller your trigs are, the more of the "leftover" number in the equation gets attributed to LDL, and that’s really misleading.

CHOLESTEROL RATIOS, AND WHY THEY’RE MORE IMPORTANT THAN TOTAL CHOLESTEROL


There are three ratios that scientists have found which measure the impact of cholesterol in the body. These are the ratios between the total amount of cholesterol measured and the HDL (Total/HDL), between triglycerides and HDL (Trig/HDL), and between LDL and HDL (LDL/HDL). Each one is an indicator of something different. Many doctors don’t pay attention to these ratios, and that’s a shame, because they’re a far better indicator of cardiovascular health than the total cholesterol number. You’ll see why in a minute.
The ideal ratio of Total/HDL is 4.4 for women and 5 for men. Also, according to Your Medical Detective and several other sites, the ratio of your trigs to your HDL will indicate whether your LDL is small and dense (bad – Pattern B) or large and fluffy (neutral – Pattern A). A larger number indicates smaller LDL particles and a smaller number indicates larger LDL particles. It’s an inverse relationship.


The ideal ratio of Trig/HDL is 2 or below. 4 is high. 6 is "danger!!" This ratio indicates the level of risk for heart disease. Additionally, a low ratio of Trig/HDL is great because it’s a semi-reliable indicator of lower free insulin levels. Lower free insulin is good. (However, this doesn’t appear to work for those of African descent, so take that with a grain of salt.)


The ideal ratio of LDL to HDL is 4.3 or lower. 4.4 to 7.1 is average. 7.1 to 11 is moderate. 11 or more means you’re at high risk for developing heart disease. The ratio of LDL to HDL is considered to be a marker of carotid plaque, or how much plaque you have built up in your arteries.

THE BOTTOM LINE

So if we look at Joe’s results (using the Iranian equation), his ratios are:
Total/HDL: 250/70 or 3.57 (ideal = 5 or below)
Trig/HDL: 40/70 or 0.57 (ideal = 2 or below)
LDL/HDL: 129/70 or 1.84 (ideal = 4.3 or below)
Even if we use the Friedewald equation (with its misleading, overestimated LDL), Joe still does pretty well:
Total/HDL: 250/70 or 3.57 (ideal = 5 or below)
Trig/HDL: 40/70 or 0.57 (ideal = 2 or below)
LDL/HDL: 172/70 or 2.45 (ideal = 4.3 or below)
In all cases, Joe’s ratios are well below the "ideal" – and being below the ideal is awesome. And look at that ratio of trigs to HDL! It’s a great indicator of lower free insulin levels for Joe, and the ratio of Total/HDL also says that his LDL is probably (mostly) Pattern A.
Let’s compare that to Pat, who’s been on a low-fat, high-carb diet and exercising with chronic cardio, and whose doctor thinks he’s doing really well because his cholesterol tests came back with these numbers:
Total: 180
HDL: 25
LDL (calculated with the basic Friedewald equation): 131, or (calculated with the Iranian equation): 153
Triglycerides: 120
Pat’s ratios are:
Total/HDL: 180/25 or 7.2 (ideal = 5 or below)
Trig/HDL: 120/25 or 4.8 (ideal = 2 or below)
LDL/HDL: 131/25 or 5.24 (Friedewald LDL); 153/25 or 6.12 (Iranian LDL) (ideal = 4.3 or below)
Compared to Joe, Pat’s got one foot in a heart disease grave! His Total/HDL is way above the ideal, his trig/HDL is in the "nearly danger" zone, and his LDL/HDL says "Look, you’re at average risk for heart disease and heading higher." But if the doctor only focuses on total cholesterol, Joe’s the one who’ll be put on a statin, while Pat might be advised to find ways to bring up that HDL number a little bit, if his doctor does anything other than congratulate him on his "good" cholesterol numbers. And way too many doctors focus only on total cholesterol.

References:

http://www.mayoclinic.com/health/cho…levels/CL00001 for information on recommended cholesterol levels
http://www.proteinpower.com/drmike/w…king-the-myth/ for more information about cholesterol generally
http://www.atherotech.com/images/vap…sterolTest.pdf for more information about the specific results of a VAP test
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664115/ for information about the ratio of triglycerides to HDL
http://www.lipidsonline.org/news/article.cfm?aid=8583 has an article about the LDL/HDL ratio
http://www.healthtipscity.com/cholesterol/LDL-HDL.php has the numbers I cited for LDL/HDL ratio level meanings
http://www.atherotech.com/images/vap…VAPResults.pdf has information about insulin resistance raising Pattern B cholesterol.

Other information about cholesterol was found in Anthony Colpo’s book "The Great Cholesterol Con" (which is entirely based on peer-reviewed research), the Protein Power books by Drs. Michael and Mary Dan Eades, Gary Taubes’ "Good Calories, Bad Calories" (again, with a ton of peer-reviewed research), and Mark Sisson’s "Primal Blueprint."

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