New study from Japan showing that low intensity training improves insulin sensitivity and decreasing fasting insulin levels. Great for those looking to lose weight and control there diabetes, but for the rest of us there are added bonuses. Low intensity training also was found to decrease IGF-I and increase IGF-BP’s. A high Insulin-like Growth Factor-I (IGF-I) to Insulin-like Growth Factor – Binding Protein (IGF-BP) ratio is associated with increased risk of developing various cancers (amongst other other nasty things) so by performing low-intensity exercise and lowering your IGF-I and increasing your IGF-BP you are reducing your risk of developing cancers!
Effect of low-intensity aerobic exercise on insulin-like growth factor-I and insulin-like growth factor-binding proteins in healthy men.
Increased concentrations of circulating insulin-like growth factor-I (IGF-I) or IGF-I relative to IGF-binding proteins (IGFBPs) are associated with increased risk of developing several forms of cancer. Conversely, exercise is linked with reduced risk. This study aims to investigate the effect of a low-intensity exercise program on circulating levels of IGF-I, IGFBP-1, and IGFBP-3, in previously sedentary males. Fourteen healthy men participated in cycle ergometer training at lactate threshold intensity for 60 min/day, 5 days/week for 6 weeks. After aerobic training, insulin sensitivity improved by 20%, while fasting insulin levels decreased by 13%. Simultaneously, low-intensity aerobic training decreased the circulating levels of IGF-I by 9%, while IGFBP-1 levels increased by 16%. An interesting finding was that higher pretraining level of IGF-I was associated with greater decline in IGF-I with training. Insulin-sensitizing low-intensity aerobic exercise is thus considered to be an effective method for downregulating IGF-I and upregulating IGFBP-1 levels.